Transcription factor function in development and disease

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How do transcription factors inputs and enhancers define transcription dynamics?

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Regulation of the expression dynamics of the ergosterol pathway in Saccharomyces and Candida yeasts

Does cell shape direct polarisation and force propagation within the developing zebrafish neural tube?

Characterisation and structural analysis of the pro-peptide region in regulating collagen homeostasis

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Primary cilium mediated interpretation of signalling during neuronal differentiation in the developing vertebrate embryo

Hungry tissues:

Understanding how energy metabolism fuels morphogenesis

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Understanding how translation elongation regulates protein synthesis in the response to oxidative stress

Genetic network controlling somatic embryogenesis during Kalanchoë plantlet development

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Understanding the secretory pathway in health and disease

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Investigating the structure and dynamics of G protein-coupled receptors by EPR Spectroscopy and other cutting-edge methodologies

Investigating translation and assembly of secretory and membrane protein complexes

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Delineating the gene expression timeline of a mitochondrial stress response regulating ageing

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Control of ribosome frameshifting in response to oxidative stress

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Exploiting the variation in cellulose synthesis to generate novel renewable biomaterials

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