The vision behind our research is to draw a broad picture of how gene expression is controlled by RNA synthesis
in normal and diseased eukaryotic cells
We are interested in different aspects of RNA biology,
from transcription to RNA degradation
We aim to reveal novel functions for processing and termination factors which are recruited to the C-terminal domain (CTD) of RNA Polymerase II (Pol II) and are involved in all steps of RNA synthesis. Elucidating how these essential factors police RNA biology will allow us to understand the principles of gene expression regulation and the molecular basis of genetic diseases.
In our research, we employ a model organism Saccharomyces cerevisiae and human cell lines.