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Pawel Grzechnik lab at the University of Birmingham

Faculty of Biology, Medicine and Health

School of Biological Sciences

Division of Molecular and Cellular Function

We study the mechanisms regulating RNA Polymerase II
co-transcriptional RNA processing in normal and diseased eukaryotic cells


The Team

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  • Zanin O., Eastham E., Winczura K., Ashe M., Martinez-Nunez R.T., Hebenstreit D., Grzechnik P. (2023) Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs.  Commun. Biol. 6 (112); doi:10.1038/s42003-023-05495-6 [PDF]


  • Sledziowska M., Jones M., Almaghrabi R., Hebenstreit D., Garcia P., Grzechnik P. (2022) Non-coding RNAs associated with Prader-Willi syndrome regulate transcription of neuronal genes in human induced pluripotent stem cells.  Hum. Mol. Gen. doi:20.1093/hmg/ddac228 [PDF]

  • Winczura K., Ceylan H., Sledziowska M., Jones M., Fagarasan H., Wang J., Saponaro M., Arnold R., Hebenstreit D., Grzechnik P. (2021) RPRD proteins regulate transcription in human cells. BioRxiv; doi:10.1101/2021.06.20.449126;  [PDF]

  • Heo D.H, Kus K., Grzechnik P., Tan-Wong S.M., Birot A., Kecman T., Nielsen S., Zenkin N., Vasiljeva L. (2021) Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Cell Rep. 36, doi:10.1016/j.celrep.2021.109671 [PDF]


  • Melidis L., Hill H.J., Coltman N.J., Davies S.P., Winczura K., Chauchan T., Craig J.S., Garai A., Hooper C.J., Edgan R.T., McKeating J.A., Hodges N.J., Stamataki Z.*, Grzechnik P.*, Hannon M.J.* (2021). Supramolecular cylinders target bulge structures in the 5’ UTR of the RNA genome of SARS-Cov-2 and inhibit viral replication. Angew. Chem. doi:10.1002/anie.202104179; BioRxiv doi:10.1101/2021.03.30.437757; *joint communication author [PDF]

  • Winczura K.M., Grzechnik P. (2019) DNAzyme-dependent analysis of rRNA 2’-O-methylation. JoVE, 151, doi: 10.3791/59700. [PDF]

  • Kufel J., Grzechnik P. (2019) snoRNAs tell a different tale. Trends Genet., 35, 104-117, doi: 10.1016/j.tig.2018.11.005 Review. [PDF]

  • Pettinati I., Grzechnik P., Ribeiro de Almeida C., Brem J., McDonough M.A., Dhir S., Gannon J., Proudfoot N.J., Schofield C.J. (2018) Biosynthesis of histone messenger RNA employs a specific 3’ endonuclease. eLife, 7 pii:398865, doi: 10.7554/eLife.39865 [PDF]

  • Lidschreiber M., Easter A.D., Battaglia S., Rodríguez-Molina R.B., Casañal A., Carminati M., Baejen C., Grzechnik P., Maier K.C., Cramer P., Passmore L.A. (2018) The APT complex is involved in non-coding RNA transcription and is distinct from CPF. Nucleic Acids Res. 46,11528-38 [PDF]

  • Grzechnik P.*, Szczepaniak A.S., Dhir S., Pastucha A., Parslow H., Matuszek Z., Mischo H., Kufel J., Proudfoot N.J. (2018) Nuclear fate of yeast snoRNA is determined by co-transcriptional Rnt1 cleavage. Nat. Commun., 9:1783. *joint communication author [PDF]

  • Grzechnik P., Gdula M. R., Proudfoot N.J. (2015) Pcf11 orchestrates transcription termination pathways in yeast. Genes Dev. 29, 849-61. [PDF]

  • Grzechnik P., Tan-Wong S.M., Proudfoot N.J. (2014) Terminate and make a loop: regulation of transcriptional directionality. Trends Biochem. Sci. 39, 319-327. Review. [PDF]

  • Skowronek E., Grzechnik P., Späth B., Marchfelder A., Kufel J. (2014) tRNA 3' processing in yeast involves tRNase Z, Rex1, and Rrp6. RNA 20, 115-30. [PDF]

  • Mischo H.E., Gómez-González B., Grzechnik P., Rondón A.G., Wei W., Steinmetz L., Aguilera A., Proudfoot N.J. (2011) Yeast Sen1 helicase protects the genome from transcription-associated instability. Mol. Cell 41, 21-32. [PDF]

  • Grzechnik P., Kufel J. (2008) Polyadenylation linked to transcription termination directs the processing of snoRNA precursors in yeast. Mol. Cell 32, 247-58. [PDF]

  • Piwowarski J., Grzechnik P., Dziembowski A., Dmochowska A., Minczuk M., Stepien P. P. (2003) Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria. J. Mol. Biol. 329, 853-7. [PDF]

Join us

Join us

If you are interested in RNA biology and would like to join the lab as an undergraduate student, a PhD student or a postdoc,

contact Pawel directly: 

pawel.grzechnik (at)


If you wish to apply for your own funding we will help you to develop your project and application.

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